Keys has co-starred in a film alongside Ben Affleck, Ray Liotta, Common, Andy Garcia, Jeremy Piven, and Ryan Reynolds entitled Smokin' Aces, released on January 26, 2007, as an assassin named Georgia Sykes. Keys has received much praise from her co-stars in the film; Ryan Reynolds said Keys has "natural" acting ability as he was surprised she had not starred in films before.
Furthermore, in her second film, The Nanny Diaries, released on August 24, 2007, Keys co-stars alongside Scarlett Johansson and Chris Evans as Lynette, Johansson's character Annie's best friend. The Kingsborough Community College in Brooklyn, New York was used to film the college graduation scene for the film.
Keys and her long-term manager Jeff Robinson have signed a first-look film production deal to develop live-action and animated projects with Disney, Variety reports. Their first film, a remake of the 1958 comedy Bell, Book and Candle, will star Keys as a witch who casts a love spell to lure a rival's fiance. Keys and Robinson have also formed a television production company called Big Pita. Their first project will be a CW Network TV series inspired by Keys' experiences as a biracial child growing up in New York, similar to the network's Everybody Hates Chris. Keys has been tapped to executively produce an upcoming TV drama. The title and airing date are presently unconfirmed. Keys and Robinson said they will develop live-action and animated projects at their company, Big Pita, Little Pita, with Keys participating as producer, thesp, banner spearheading soundtrack, and music supervision. She also played a voice in the "Mission to Mars" episode of The Backyardigans.
Keys will also play 1940s biracial piano child prodigy Philippa Schuyler in an upcoming film entitled Composition in Black and White. It is based on the 1995 biographical book of the same name by Kathryn Talalay and follows the story of Philippa Schuyler. "The challenge, in order to actually be able to play classical piano as a woman of mixed race, was by far more than I could ever imagine", Keys said. "That's what intrigued me about that role". The biopic will tell the difficult tale of Schuyler's controversial career, love-hate relationship with her mother, and the black community, her second career as a writer, and her eventual death in a helicopter accident. "Her story is very deep, even up to the point where the relationship between her and her mother gets very strained and she chooses to go to Europe and pass as a Spanish woman in order to be able to play, in order to be able to live a more normal life", Keys said, adding that she and Halle Berry hope to start shooting in early 2008. "As of right now, we're still in the first, second draft of the script", she said. "So a little bit of time—at least a year".